1. Django A Python web framework that encourages rapid development and clean, pragmatic design.
2. Web2Py A full-stack framework for fast, scalable, secure, and portable database-driven web applications.
3. Bottle A fast, simple, and lightweight WSGI micro web-framework for Python.
4. FastAPI A high-performance web framework for building APIs with Python.
5. Masonite The modern and developer-centric Python web framework.
6. Pyramid Makes it easy to write web applications.
7. Tornado A Python web framework and asynchronous networking library.
8. Falcon A Python web API framework for building reliable app backends and microservices.
9. Sanic A Python web framework designed for fast HTTP responses via asynchronous request handling.
10. TurboGears The web framework that scales with you.
11. Pycnic A JSON API web framework for lazy people.
12. Flask A web application framework written in Python, based on the Werkzeug WSGI toolkit and Jinja2 template engine.